Source: BELTSVILLE AGR RES CENTER submitted to
INSULIN ENHANCING PRODUCTS FROM CINNAMON
 
PROJECT DIRECTOR: ANDERSON R A
 
PERFORMING ORGANIZATION
(N/A)
BELTSVILLE AGR RES CENTER
BELTSVILLE,MD 20705
 
NON TECHNICAL SUMMARY:
 
OBJECTIVES: This study is designed to determine if the water extract of cinnamon, which is high in polyphenols, improves antioxidant status of rats fed a high fructose diet to induce decreased insulin sensitivity.
 
APPROACH: Weanling Wistar rats, males, will be fed a fructose rich diet which is known to produce insulin resistance and early signs of the metabolic syndrome. This rat model mimics early signs of type 2 diabetes. Group I will receive ad libitum the fructose rich diet; Group II the fructose rich diet containing 0.2 g of water extract of cinnamon (Cinnulin)/100g of diet and Group III the fructose rich diet containing 2 g of Cinnulin per g diet (Cinnulin will be provided by CRADA partner, Integrity Nutraceuticals). Blood sampling and tissue (kidney, muscle, pancreas and liver) removal will take place at the beginning of week 9. Samples related to antioxidant variables will be analyzed in laboratory of collaborator in France and samples regarding insulin function sent to ARS laboratory for analyses.
 
CRIS NUMBER: 0410118 SUBFILE: CRIS
PROJECT NUMBER: 1235-51520-037-06T SPONSOR AGENCY: ARS
PROJECT TYPE: USDA INHOUSE PROJECT STATUS: TERMINATED MULTI-STATE PROJECT NUMBER: (N/A)
START DATE: Jan 2, 2003 TERMINATION DATE: Jan 1, 2008

GRANT PROGRAM: (N/A)
GRANT PROGRAM AREA: (N/A)

CLASSIFICATION
Knowledge Area (KA)Subject (S)Science (F)Objective (G)Percent
702601010105.1100%

CLASSIFICATION HEADINGS
KA702 - Requirements and Function of Nutrients and Other Food Components
S6010 - Individuals
F1010 - Nutrition and metabolism
G5.1 - Ensure Access to Nutritious Food


RESEARCH EFFORT CATEGORIES
BASIC 100%
APPLIED 0%
DEVELOPMENTAL 0%

KEYWORDS: CINNAMON SPICES POTENTIATING DIABETES ACTIVITY

PROGRESS: Oct 1, 2006 TO Sep 30, 2007
Progress Report Objectives (from AD-416) This study is designed to determine if the water extract of cinnamon, which is high in polyphenols, improves antioxidant status of rats fed a high fructose diet to induce decreased insulin sensitivity. Approach (from AD-416) Weanling Wistar rats, males, will be fed a fructose rich diet which is known to produce insulin resistance and early signs of the metabolic syndrome. This rat model mimics early signs of type 2 diabetes. Group I will receive ad libitum the fructose rich diet; Group II the fructose rich diet containing 0.2 g of water extract of cinnamon (Cinnulin)/100g of diet and Group III the fructose rich diet containing 2 g of Cinnulin per g diet (Cinnulin will be provided by CRADA partner, Integrity Nutraceuticals). Blood sampling and tissue (kidney, muscle, pancreas and liver) removal will take place at the beginning of week 9. Samples related to antioxidant variables will be analyzed in laboratory of collaborator in France and samples regarding insulin function sent to ARS laboratory for analyses. Significant Activities that Support Special Target Populations This report documents research conducted under a trust agreement between ARS and Integrity Neutraceuticals International, Sarasota, FL. Additional details of research can be found in the report for the associated in-house project 1235-51520-037-00D, "Chromium and Polyphenols from Cinnamon in the Prevention and Alleviation of Glucose Intolerance". The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence that dietary factors are involved in its regulation and prevention. One group of male weanling Wistar rats was fed a high-fructose diet that has been shown to induce insulin resistance, a second group the same diet plus 0.1 g grams of dried water soluble extract of cinnamon (Cinnulin PF, to be furnished by CRADA partner), and the third group the high fructose diet plus 2 g of Cinnulin PF. Animals have been fed the diet and samples are being analyzed. Conference calls were held on a bi-monthly basis and two yearly on-site visits were made by the cooperator.

IMPACT: 2006-10-01 TO 2007-09-30

PUBLICATION INFORMATION: 2006-10-01 TO 2007-09-30


PROJECT CONTACT INFORMATION
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